How long must symptoms persist to consider major depressive syndrome?

To consider a diagnosis of major depressive syndrome, symptoms must persist for at least two weeks. This criterion is based on the guidelines set forth in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), which is widely used in clinical settings. A minimum duration of two weeks of experiencing symptoms such as depressed mood or loss of interest or pleasure in most activities is critical for establishing the diagnosis of a major depressive episode. This duration helps differentiate between a transient mood disturbance and a more severe, clinically significant depressive disorder, ensuring that individuals experiencing a depressive episode receive appropriate attention and treatment.